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January 1, 2008Journal of Vascular Research

Balance between Angiopoietin-1 and Angiopoietin-2 Is in Favor of Angiopoietin-2 in Atherosclerotic Plaques with High Microvessel Density

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Population

100 carotid endarterectomy specimens

Design

Cross-sectional

Authors

SPSimone PostUniversity Medical Center Utrecht WPWouter PeetersNewcastle University EBEls Busser

Discussion

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Implication

May link Ang-2 predominance to plaque vulnerability; hypothesis-generating for targeted therapies, needs prospective validation.

Structured PICO

P

Population

100 carotid endarterectomy specimens

O

Outcome

Correlation of Angiopoietin-1 and -2 expression patterns with plaque microvessel density (MVD)surrogate

In atherosclerotic plaques, high microvessel density is associated with a shift in the Angiopoietin balance towards Ang-2, which correlates with MMP-2 activity and may contribute to plaque destabilization.

Cite This Study

Post et al. (2008) studied this question.

synapsesocial.com/papers/6a8376eaaf1ae4bfdd72101d https://doi.org/10.1159/000112939

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; regulation by the von Hippel‐Lindau gene and hypoxia2002 · 88 citations
2Abnormal Balance in the Angiopoietin-Tie2 System in Human Brain Arteriovenous Malformations2001 · 121 citations
3Atherosclerotic Plaque Progression and Vulnerability to Rupture2005 · 1,328 citations
4Signaling Molecules in Nonfamilial Pulmonary Hypertension2003 · 397 citations
5The Tie-2 ligand Angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies2004 · 749 citations