Why the study?
Does a single dose of an oral nitric oxide supplement reduce blood pressure and improve vascular compliance and endothelial function in unmedicated hypertensive patients?
Population
30 unmedicated adults with clinical hypertension in an outpatient setting. Exclusions: medically unstable…
Comparison
Single dose of an orally disintegrating nitric… vs Matching placebo administered to 10 patients…
Design
RCT, Unequal/unbalanced randomization, Blinded placebo-controlled; patients…
Follow-up
4 hours
Authors
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Supports acute BP lowering with oral NO in unmedicated hypertension; extends RCT evidence on vascular compliance and endothelial function.
Does a single dose of an oral nitric oxide supplement reduce blood pressure and improve vascular compliance and endothelial function in unmedicated hypertensive patients?
A single administration of an oral nitric oxide supplement acutely lowers blood pressure, improves vascular compliance, and restores endothelial function in unmedicated hypertensive patients.
Houston et al. (2014) studied this question.
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