Why the study?
Does angiotensin II infusion preserve vasodilator reactivity via AT1 receptors in skeletal muscle resistance arteries of rats on a high-salt diet?
Population
Normotensive Sprague-Dawley rats placed on a high-salt (HS) diet (4.0% NaCl) for 3-7 days
Comparison
Continuous intravenous infusion of angiotensin… vs Coinfusion of the AT1 receptor blocker losartan…
Design
Preclinical
Follow-up
3 days
Authors
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Supports AT1 mediation of ANG II protection in high-salt rat arteries; hypothesis-generating and requires validation in human studies.
Does angiotensin II infusion preserve vasodilator reactivity via AT1 receptors in skeletal muscle resistance arteries of rats on a high-salt diet?
Angiotensin II preserves vasodilator reactivity in skeletal muscle resistance arteries during high-salt intake via the AT1 receptor.
Weber et al. (2001) studied this question.
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