December 5, 2020Artificial Organs
Use of extracorporeal membrane oxygenation in high‐risk acute pulmonary embolism: A systematic review and meta‐analysis
Why the study?
ECMO represents a therapeutic option for cardiopulmonary support in high-risk pulmonary embolism, but no definite consensus exists regarding its use.
What are the clinical outcomes and adverse events associated with ECMO use in patients with high-risk acute pulmonary embolism?
Population
635 patients with high-risk PE across 21 studies
Comparison
ECMO support (single-arm pooled analysis)
Design
Systematic review and meta-analysis
Authors
Discussion
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Member takes
Implication
High early mortality with ECMO in high-risk PE warrants caution; leaves open optimal selection and RCTs to define benefit.
Structured PICO
What are the clinical outcomes and adverse events associated with ECMO use in patients with high-risk acute pulmonary embolism?
P
Population
635 patients with high-risk acute pulmonary embolism from 21 studies, mean age 47.8 ± 17.3 years, 44.5% females.
I
Intervention
Extracorporeal membrane oxygenation (ECMO)
O
Outcome
Early all-cause deathhard clinical
In patients with high-risk pulmonary embolism, ECMO support is associated with an early all-cause mortality of 41.1% and a major bleeding rate of 28.6%.
Cite This Study
Baldetti et al. (2020) studied this question.