August 5, 2013Critical CareOpen Access

A high angiopoietin-2/angiopoietin-1 ratio is associated with a high risk of septic shock in patients with febrile neutropenia

View Full Paper

Ask AI

Bookmark

Why the study?

Does a high Ang-2/Ang-1 ratio predict the development of septic shock in cancer patients with febrile neutropenia?

Structured PICO

Does a high Ang-2/Ang-1 ratio predict the development of septic shock in cancer patients with febrile neutropenia?

Population

99 cancer patients with chemotherapy-associated febrile neutropenia (FN) and severe neutropenia (absolute neutrophil count <0.5 × 10⁹/L), enrolled within 24 hours from admission.

Intervention

Measurement of serum levels of VEGF-A, sFlt-1, Ang-1, and Ang-2, and calculation of the Ang-2/Ang-1 ratio.

Outcome

Development of septic shock at any time point before the resolution of FN or at a maximum of 28 days after enrollment.hard clinical

A high Ang-2/Ang-1 ratio is an independent predictor of septic shock and 28-day mortality in cancer patients with chemotherapy-associated febrile neutropenia.

Limitations

Relatively low sensitivity and specificity of the Ang-2/Ang-1 ratio

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May inform risk stratification in febrile neutropenia; hypothesis-generating pending prospective validation.

Cite This Study

Fiusa et al. (2013) studied this question.

synapsesocial.com/papers/6a813c8fe6814737203c0ae7 https://doi.org/10.1186/cc12848

View Full Paper

Ask AI

Bookmark