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Thrombopoietin is a hepatic hormone that stimulates platelet production and is regulated by the mass of megakaryocytes and platelets.
The glycoprotein thrombopoietin (TPO) is the major stimulator of megakaryopoiesis and platelet production. Hepatocytes express TPO mRNA at a constant rate. The plasma TPO level is inversely correlated to the mass of megakaryocytes and platelets, which degrade the hormone following its binding to specific membrane receptors.
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Wolber et al. (2002) studied this question.
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