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January 27, 2021Experimental PhysiologyOpen Access

Short-term sustained hypoxia in mice resulted in normal MAP, reduced baseline HR, increased baseline respiratory frequency, increased cervical vagus nerve activity, and reduced thoracic sympathetic nerve activity during expiration.

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Why the study?

Consistent data on the autonomic and respiratory effects of sustained hypoxia in mice were lacking, and in situ nerve recordings had not been performed.

Does short-term sustained hypoxia alter autonomic and respiratory patterns in mice?

Population

Mice

Comparison

Short-term sustained hypoxia (for 24 h) vs baseline/control

Design

Animal physiological study including in situ working heart-brainstem preparations

Authors

KRKarla Lima RodriguesJSJuliana R. SouzaDBDarlan S. Bazilio

Discussion

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Member takes

Overview

Provides a mouse model for hypoxia-induced autonomic-respiratory coupling; leaves open translation to human cardiovascular disease.

Structured PICO

Does short-term sustained hypoxia alter autonomic and respiratory patterns in mice?

P
Population
Mice (behaving and in situ working heart-brainstem preparation)
I
Intervention
Short-term sustained hypoxia (FiO2 = 0.1 for 24 h)
C
Comparator
Normoxic conditions (implied baseline/control)
O
Outcome
Changes in baseline mean arterial pressure (MAP), heart rate (HR), respiratory frequency (fR), and autonomic/respiratory nerve activitiessurrogate

Mice exposed to short-term sustained hypoxia exhibit distinct autonomic and respiratory changes, making them a valuable model for studying respiratory-sympathetic coupling.

Cite This Study

Rodrigues et al. (2021) studied this question.

synapsesocial.com/papers/6a8154d8267334e2baf092echttps://doi.org/10.1113/ep089323
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Short‐term sustained hypoxia induces changes in the coupling of sympathetic and respiratory activities in rats2014 · 68 citations
  2. 2Sustained hypoxia in mice increases parasympathetic but not sympathetic tone2022 · 6 citations
  3. 3Short-Term Sustained Hypoxia Elevates Basal and Hypoxia-Induced Ventilation but Not the Carotid Body Chemoreceptor Activity in Rats2018 · 21 citations
  4. 4Sympathoexcitatory response to peripheral chemoreflex activation is enhanced in juvenile rats exposed to chronic intermittent hypoxia2006 · 65 citations
  5. 5Postsynaptic changes increase the excitability of NTS neurons of mice exposed to hypoxia rather than presynaptic or astrocyte‐related mechanisms2025 · 3 citations