Population
Juvenile male Holtzman rats (60-80 g)
Comparison
Short-term sustained hypoxia (10% O2 for 24 h) vs Normoxia (control)
Design
Preclinical
Follow-up
24 hours
Key result
Exposure to 24 hours of sustained hypoxia significantly elevated baseline minute ventilation (155.0 vs 97.9 ml/100g/min) in juvenile rats without increasing basal carotid body chemoreceptor activity.
Authors
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Short-term hypoxia may elevate ventilation independently of basal carotid body activity in juvenile rats; leaves open mechanisms and human translation.
Absolute Event Rate: 155% vs 97.9%
p-value: p=0.0042
Short-term sustained hypoxia in rats increases resting ventilation and sympathetic overactivity independently of increased basal and sensorial activity of carotid body chemoreceptors.
Flor et al. (2018) studied Hypoxia (n=40). Sustained hypoxia vs. Normoxia (21% O2) was evaluated on Minute ventilation (VE) under resting conditions (normoxia/normocapnia) (p=0.0042). Exposure to 24 hours of sustained hypoxia significantly elevated baseline minute ventilation (155.0 vs 97.9 ml/100g/min) in juvenile rats without increasing basal carotid body chemoreceptor activity.
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