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March 11, 2014The Journal of PhysiologyOpen Access

Sustained hypoxia for 24 h induced an active expiratory pattern and high thoracic sympathetic activity, which was abolished by antagonism of ionotropic glutamatergic receptors in the BötC/RVLM.

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Population

Juvenile rats (decerebrated arterially perfused in situ preparation)

Comparison

Sustained hypoxia (10% O2) for 24 hours vs Normoxia (implied control)

Design

Preclinical

Follow-up

24 hours

Authors

DMDavi J. A. MoraesLBLeni G. H. BonagambaKCKauê Machado Costa

Discussion

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Overview

May inform mechanisms of hypoxia-related sympathetic activation; hypothesis-generating for human cardiorespiratory disorders.

Structured PICO

P
Population
Juvenile rats (decerebrated arterially perfused in situ preparation)
I
Intervention
Sustained hypoxia (10% O2) for 24 hours
C
Comparator
Normoxia (implied control)
O
Outcome
Changes in respiratory pattern and sympathetic outflow (neuronal activity in the Bötzinger complex and rostral ventrolateral medulla)surrogate

Short-term sustained hypoxia induces glutamate-dependent activation of medullary expiratory neurons, altering expiratory motor activity and increasing sympathetic outflow.

Cite This Study

Moraes et al. (2014) studied this question.

synapsesocial.com/papers/6a8154d8267334e2baf092f5https://doi.org/10.1113/jphysiol.2013.262212
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Also Consider

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  4. 4Entrainment pattern between sympathetic and phrenic nerve activities in the Sprague-Dawley rat: hypoxia-evoked sympathetic activity during expiration2004 · 70 citations
  5. 5Altered sympathetic reflexes and vascular reactivity in rats after exposure to chronic intermittent hypoxia2011 · 86 citations