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April 29, 2015Journal of NeuroscienceOpen Access

Enhanced Firing in NTS Induced by Short-Term Sustained Hypoxia Is Modulated by Glia-Neuron Interaction

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Population

Rats (in situ preparation and brainstem slices)

Comparison

Short-term sustained hypoxia (24 h, FIO2 10%) vs Control rats

Design

Preclinical

Follow-up

24 hours

Authors

DADaniela Accorsi‐MendonçaCACarlos Eduardo L. AlmadoLBLeni G. H. Bonagamba

Discussion

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Overview

Hypothesis-generating for glial modulation of autonomic reflexes in hypoxia; should not change clinical practice without human validation.

Structured PICO

P
Population
Rats (in situ preparation and brainstem slices)
I
Intervention
Short-term sustained hypoxia (24 h, FIO2 10%)
C
Comparator
Control rats
O
Outcome
Electrophysiological properties and synaptic transmission in the nucleus tractus solitarius (NTS) neurons, and processing of cardiovascular and respiratory reflexessurrogate

Short-term sustained hypoxia alters glia-neuron interactions to increase the excitability and excitatory transmission of NTS neurons, enhancing baroreflex and chemoreflex sensitivity.

Cite This Study

Accorsi‐Mendonça et al. (2015) studied this question.

synapsesocial.com/papers/6a8154d8267334e2baf092f3https://doi.org/10.1523/jneurosci.4598-14.2015
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