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April 1, 1995Hypertension

Antihypertensive Actions of the Novel Nonpeptide Endothelin Receptor Antagonist SB 209670

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Why the study?

Does the endothelin receptor antagonist SB 209670 reduce blood pressure in hypertensive rat models?

Population

Conscious, unrestrained spontaneously hypertensive, normotensive Wistar-Kyoto, and renin-hypertensive rats

Comparison

SB 209670 administered via sustained intravenous… vs Normotensive WKY rats and baseline measurements

Design

Preclinical

Follow-up

Up to 6 hours

Authors

SDStephen A. DouglasUniversity of MinnesotaMGMiklos GellaiDartmouth CollegeMEMildred EzekielUnited States Department of Veterans Affairs

Discussion

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Implication

Supports endothelin-1 role in experimental hypertension; leaves open translation to human therapy.

Structured PICO

Does the endothelin receptor antagonist SB 209670 reduce blood pressure in hypertensive rat models?

P
Population
Conscious, unrestrained spontaneously hypertensive (SHR), normotensive Wistar-Kyoto (WKY), and renin-hypertensive rats
I
Intervention
SB 209670 (nonpeptide endothelin receptor antagonist) administered via sustained intravenous infusion (10 micrograms.kg-1.min-1 for 6 hours), intraduodenal administration (3 mg/kg), or intravenous bolus (3 mg/kg)
C
Comparator
Normotensive WKY rats (for SHR comparison) and baseline measurements
O
Outcome
Mean arterial pressuresurrogate

The novel endothelin receptor antagonist SB 209670 effectively lowers blood pressure in hypertensive rat models, highlighting the role of endothelin-1 in hypertension.

Cite This Study

Douglas et al. (1995) studied this question.

synapsesocial.com/papers/6a815e8fadfa6baaaee1cf5chttps://doi.org/10.1161/01.hyp.25.4.818

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1BQ-123, a selective endothelin subtype A-receptor antagonist, lowers blood pressure in different rat models of hypertension1994 · 47 citations
  2. 2Captopril prevents chronic hypertension produced by infusion of endothelin-1 in rats.1992 · 37 citations
  3. 3Central effect of endothelin on blood pressure in conscious rats1989 · 84 citations
  4. 4Suppression of baroreceptor discharge by endothelin at high carotid sinus pressure1992 · 43 citations
  5. 5Effects of WAY-123,398, a New Class III Antiarrhythmic Agent, on Cardiac Refractoriness and Ventricular Fibrillation Threshold in Anesthetized Dogs: A Comparison with UK-68798, E-4031, and dl-Sotalol1992 · 62 citations