Why the study?
Does alpha1A-AR or alpha1B-AR activation protect the heart from ischemic injury?
Population
Isolated hearts from transgenic mice expressing constitutively active mutant forms of the alpha1A-AR or the…
Comparison
Expression of CAM alpha1A-AR or alpha1B-AR… vs Non-transgenic hearts; non-preconditioning…
Design
Preclinical
Follow-up
40-min reperfusion
Authors
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Alpha1A-AR activation may protect rodent hearts from ischemia; leaves open translation to human cardioprotection.
Does alpha1A-AR or alpha1B-AR activation protect the heart from ischemic injury?
Alpha1A-adrenergic receptors, but not alpha1B-adrenergic receptors, protect the heart from ischemic injury through a staurosporine-sensitive, protein kinase C-independent pathway.
Rorabaugh et al. (2004) studied this question.
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