Why the study?
The study aimed to evaluate lipid profile features across different renin-angiotensin-aldosterone system activity levels in patients with arterial hypertension and concomitant obesity.
Does the activity of the renin-angiotensin-aldosterone system affect the lipid profile in patients with essential hypertension and obesity?
Does the activity of the renin-angiotensin-aldosterone system affect the lipid profile in patients with essential hypertension and obesity?
Patients with essential hypertension and obesity who have low-renin activity exhibit a less atherogenic lipid profile compared to those with high-renin activity.
Low-renin hypertension was associated with less atherogenic lipids in obese patients; hypothesis-generating and leaves open causal RAAS effects.
The objective: the aim of the study was to evaluate the features of the lipid profile in the case of different activity of the components of the renin-angiotensin-aldosterone system in patients with arterial hypertension (AH) and concomitant obesity.Materials and methods.188 patients with essential hypertension (EH) and obesity I–II degrees were examined (who gave informed written consent to participate in the study and met the inclusion criteria). The control group consisted of 25 practically healthy individuals, matched by age and sex with the main group patients.Results. It was established that in patients with comorbidity of EH and obesity I–II degrees, the low-renin AH (LRAH) was found in 9,4% of cases. The LRAH and high-renin AH (HRAH) in obese patients did not differ in anthropometric indices.Conclusion. In the presence of LRAH in patients with obesity I–II degrees the levels of atherogenic lipoproteins were significantly lower than in HRAH.
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Kochuieva et al. (2019) studied this question.
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