July 1, 2006Hormone and Metabolic Research

Increased Aldosterone/Renin Quotient in Obese Hypertensive Women: A Novel Role for Low-density Lipoproteins?

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Population

Obese hypertensive women and obese normotensive women, as well as an in vitro model using human…

Design

Cross-sectional

Authors

VLValéria Lamounier‐ZepterTechnische Universität Dresden TRThomas RotthoffTechnische Hochschule Augsburg IAIshrath AnsurudeenKarolinska Institutet

Discussion

Member takes

Implication

LDL may link to hypertension via aldosterone in obese women; hypothesis-generating cross-sectional data leaves open causal role and need for trials.

Structured PICO

Population

Obese hypertensive women and obese normotensive women, as well as an in vitro model using human adrenocortical H295R cells.

Outcome

Plasma levels of renin, aldosterone, insulin, HDL, LDL, and aldosterone/renin quotient (ARQ); angiotensin II-stimulated aldosterone release in vitro.surrogate

Increased LDL-cholesterol in obese hypertensive women may contribute to hypertension by sensitizing adrenocortical cells to angiotensin II, thereby increasing the aldosterone/renin quotient.

Cite This Study

Lamounier‐Zepter et al. (2006) studied this question.

synapsesocial.com/papers/6a7d4147fac401f278425bce https://doi.org/10.1055/s-2006-948137

Topics

Hypertension management

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Implication

LDL may link to hypertension via aldosterone in obese women; hypothesis-generating cross-sectional data leaves open causal role and need for trials.

Increased Aldosterone/Renin Quotient in Obese Hypertensive Women: A Novel Role for Low-density Lipoproteins?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Increased Aldosterone/Renin Quotient in Obese Hypertensive Women: A Novel Role for Low-density Lipoproteins?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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