Key result
High-renin hypertension is linked to higher LDL-C and total cholesterol than low-renin hypertension.
Why the study?
Does high plasma renin activity correlate with worse serum lipid profiles in untreated patients with stage 1 primary arterial hypertension?
Cross-Sectional (n=97)
No
Does high plasma renin activity correlate with worse serum lipid profiles in untreated patients with stage 1 primary arterial hypertension?
High-renin primary arterial hypertension is associated with higher total and LDL cholesterol levels, though the linear correlation between renin activity and LDL-C is only present in low-renin patients.
Answers are grounded in this paper and cite their sources.
May support lipid assessment in high-renin hypertension; leaves open causal mechanisms and need for prospective validation.
Introduction: The aim of the study was to evaluate clinical and biochemical differences between patients with low-renin and high-renin primary arterial hypertension (AH), mainly in reference to serum lipids, and to identify factors determining lipid concentrations. Materials and methods: In untreated patients with AH stage 1 we measured plasma renin activity (PRA) and subdivided the group into low-renin (PRA < 0.65 ng/mL/h) and high-renin (PRA ⩾ 0.65 ng/mL/h) AH. We compared office and 24-h ambulatory blood pressure, serum aldosterone, lipids and selected biochemical parameters between subgroups. Factors determining lipid concentration in both subgroups were assessed in regression analysis. Results: Patients with high-renin hypertension ( N = 58) were characterized by higher heart rate ( p = 0.04), lower serum sodium ( p < 0.01) and aldosterone-to-renin ratio ( p < 0.01), and significantly higher serum aldosterone ( p = 0.03), albumin ( p < 0.01), total protein ( p < 0.01), total cholesterol ( p = 0.01) and low-density lipoprotein cholesterol (LDL-C) ( p = 0.04) than low-renin subjects ( N = 39). In univariate linear regression, only PRA in the low-renin group was in a positive relationship with LDL-C ( R 2 = 0.15, β = 1.53 and p = 0.013); this association remained significant after adjustment for age, sex, and serum albumin and aldosterone concentrations. Conclusions: Higher serum levels of total and LDL-C characterized high-renin subjects, but the association between LDL-C level and PRA existed only in low-renin primary AH.
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Pizon et al. (2018) conducted a cross-sectional in Primary arterial hypertension (stage 1) (n=97). High plasma renin activity (PRA >= 0.65 ng/mL/h) vs. Low plasma renin activity (PRA < 0.65 ng/mL/h) was evaluated on Low-density lipoprotein cholesterol (LDL-C, mmol/L) (p=0.04). High-renin hypertension was associated with higher LDL-C and total cholesterol than low-renin hypertension.
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