What question did this study set out to answer?

To examine the association of endogenous nitric oxide synthase inhibitors and L-arginine with subclinical atherosclerosis and arterial hemodynamics.

October 14, 2008HypertensionOpen Access

Endogenous Nitric Oxide Synthase Inhibitors, Arterial Hemodynamics, and Subclinical Vascular Disease

View Full Paper

Ask AI

Bookmark

Why the study?

Are endogenous NO synthase inhibitors (ADMA and NMMA) and L-arginine associated with subclinical atherosclerosis and arterial hemodynamics in adults?

Population

922 adults participating in a population-based study (PREVENCION Study)

Design

Cross-sectional

Authors

JCJulio A. ChirinosCardiac Imaging RDRobert DavidUniversity of Rostock JBJ. Alexander BralleyNova Medical (United States)

Discussion

Member takes

Implication

Links ADMA/NMMA to carotid thickness but not stiffness; leaves open causal role in early atherosclerosis.

Key Points

To examine the association of endogenous nitric oxide synthase inhibitors and L-arginine with subclinical atherosclerosis and arterial hemodynamics.
Evaluated 922 adults participating in the population-based PREVENCION Study.
Measured circulating asymmetrical dimethylarginine (ADMA), N-guanidino-monomethyl-arginine (NMMA), and L-arginine.
Assessed carotid intima-media thickness, carotid-femoral pulse wave velocity, and hemodynamic parameters using multivariable linear regression.
Both ADMA and NMMA were significant independent predictors of carotid intima-media thickness after adjusting for cardiovascular risk factors, C-reactive protein, and renal function, whereas L-arginine was not.
Neither ADMA nor NMMA predicted carotid-femoral pulse wave velocity, blood pressure, or arterial hemodynamic abnormalities.
Higher L-arginine independently predicted systolic hypertension, higher central pulse pressure, increased incident wave amplitude, and lower total arterial compliance, without affecting systemic vascular resistance.

Structured PICO

Are endogenous NO synthase inhibitors (ADMA and NMMA) and L-arginine associated with subclinical atherosclerosis and arterial hemodynamics in adults?

Population

922 adults participating in a population-based study (PREVENCION Study)

Intervention

Endogenous NO synthase inhibitors (asymmetrical dimethylarginine [ADMA] and N-guanidino-monomethyl-arginine [NMMA]) and L-arginine levels

Outcome

Carotid intima-media thickness, carotid-femoral pulse wave velocity, and arterial hemodynamicssurrogate

Endogenous NOS inhibitors ADMA and NMMA are associated with carotid atherosclerosis but not large artery stiffness, while L-arginine is linked to abnormal pulsatile hemodynamics.

Cite This Study

Chirinos et al. (2008) studied this question.

synapsesocial.com/papers/6a816afb2bdcf510039cdcb2 https://doi.org/10.1161/hypertensionaha.108.120352

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Endogenous Nitric Oxide Synthase Inhibitors, Arterial Hemodynamics, and Subclinical Vascular Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Endogenous Nitric Oxide Synthase Inhibitors, Arterial Hemodynamics, and Subclinical Vascular Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider