June 1, 2001High Altitude Medicine & Biology
Angiotensin-Converting Enzyme and Genetics at High Altitude
Why the study?
Does the ACE gene I allele improve human endurance and performance at high altitude compared to the D allele?
Population
Humans, including elite distance runners, rowers, other elite athletes, and elite male British mountaineers…
Comparison
Presence of the ACE gene I allele vs Absence of the I allele (D allele / deletion)
Design
Review
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for athlete selection at altitude; leaves open whether ACE genotyping alters training or outcomes.
Structured PICO
Does the ACE gene I allele improve human endurance and performance at high altitude compared to the D allele?
P
Population
Humans, including elite distance runners, rowers, other elite athletes, and elite male British mountaineers who have ascended beyond 7000 m without supplemental oxygen
I
Intervention
Presence of the ACE gene I allele (insertion of a 287 bp fragment in intron 16)
C
Comparator
Absence of the I allele (D allele / deletion)
O
Outcome
Human endurance and performance at high altitude
The ACE gene I allele is associated with improved endurance and high-altitude performance, likely due to enhanced muscle efficiency.
Cite This Study
Woods et al. (2001) studied this question.