Gabapentin and Prevention of Post-Operative Nausea and Vomiting (PONV)

Background: Postoperative nausea and vomiting (PONV) is a major complication after abdominal surgery. Gabapentine has versatile role in case of convulsion and neuropathic pain management. Recently it has been used for the prevention of PONV. Objective: To evaluate the action of prophylactic gabapentin in preventing PONV in Laparoscopic cholecystectomy patients. Methods: It was a randomized placebo-controlled, double-blind study conducted in the Department of Anesthesiology, Dhaka Medical College Hospital from August 2016 to January 2017. A total number of 220 patients were selected by purposive sampling. They were divided into 2 Each group 110. After obtaining a detailed history, General physical and systemic examinations were done for all enrolled patients, after obtaining a detailed history and relevant investigations were done. The results were tested by chi-square test to see their level of significance level at <0.05. Results: Of the 220 patients, 51.81% male and 48.18% were female patients respectively belonged to the study group whereas 55.45% and 44.54% were male and female patients. The mean age of the study group and control group were 45.31±13.63 and 47.03±15.51. The mean BMI in both groups was 23.69±3.12 and 24.17±4.73. The mean arterial pressure in both groups was 96.73±8.19 and 93.35±6.37. The total mean of intravenous fluid study and control group were 1233.7±29.5 and 1139.83±55.69. The total duration of surgery in the study group was 51.77±3.95 and the control group was 46.63±7.89. From the point of view of PONV, gabapentine has shown significantly higher efficacy than placebo (P=<0.05). Out of 53 patients affected by PONV in the study group 13(24.52%), 30(56.60%), and 10(18.86%) patients were categorized as mild-moderate and severe PONV whereas 29(26.36%) 71(64.54%) and 20(18.18%) were upholder as their counterpart in the control group. In severe grade, there was no statistically significant difference found between the groups but in mild...........