Key result
Pre-emptive gabapentin cuts 24-hour postoperative tramadol use ~48% vs placebo after vaginal hysterectomy.
Why the study?
Standard postoperative analgesics have side effects and limitations, whereas gabapentin may offer opioid-sparing and anxiolytic effects without significant organ toxicities, prompting evaluation in patients undergoing vaginal hysterectomy.
Does pre-emptive gabapentin reduce postoperative pain and analgesic requirements in patients undergoing vaginal hysterectomy under spinal anesthesia?
Population
100 ASA grade I and II patients aged 40-60 years undergoing hysterectomy under spinal anesthesia
Comparison
Oral gabapentin 600mg vs placebo 1 hour before surgery
Design
Randomised double-blind study
Follow-up
24-hour period
Authors
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Supports pre-emptive gabapentin 600 mg to cut opioid use after vaginal hysterectomy; extends RCT data for multimodal regimens in gynecologic surgery.
RCT (n=100)
Double-blind
Randomized
No
Does pre-emptive gabapentin reduce postoperative pain and analgesic requirements in patients undergoing vaginal hysterectomy under spinal anesthesia?
Absolute Event Rate: 51.27% vs 98.9%
p-value: p=<0.001
A single pre-emptive dose of 600 mg oral gabapentin significantly reduces postoperative pain and tramadol consumption in patients undergoing vaginal hysterectomy under spinal anesthesia.
Pradipta Kumar Patel (2019) conducted an RCT in Postoperative pain (n=100). Gabapentin vs. Placebo was evaluated on Postoperative tramadol consumption over 24 hours (mg) (p=<0.001). A single 600 mg oral dose of pre-emptive gabapentin significantly reduced 24-hour postoperative tramadol consumption compared to placebo (51.27 mg vs 98.9 mg) in women undergoing vaginal hysterectomy.
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