Key result
Pre-emptive oral gabapentin (600 mg) significantly reduced the mean number of rescue analgesic doses required (2.1 vs 4.3, p<0.001) compared to placebo in women undergoing abdominal hysterectomy.
Why the study?
Does pre-emptive oral gabapentin 600 mg reduce postoperative pain and analgesic requirement in female patients undergoing abdominal hysterectomy?
Population
60 female patients of ASA grade I and II, age between 25-70 years, scheduled for abdominal hysterectomy…
Comparison
Oral capsule gabapentin administered two hours… vs Placebo in the form of capsule multivitamin…
Design
RCT, Randomly allocated into two groups using a computer-generated list of…
Follow-up
12 hours postoperatively
Authors
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Preoperative gabapentin 600 mg reduces pain scores and tramadol use after hysterectomy; reinforces preemptive analgesia in gynecologic surgery.
RCT (n=60)
Double-blind
Computer-generated list of random numbers
No
Does pre-emptive oral gabapentin 600 mg reduce postoperative pain and analgesic requirement in female patients undergoing abdominal hysterectomy?
Absolute Event Rate: 2.1% vs 4.3%
p-value: p=<0.001
Pre-emptive oral gabapentin 600 mg significantly reduces postoperative pain and tramadol consumption in patients undergoing abdominal hysterectomy under spinal anesthesia.
Modak et al. (2016) conducted an RCT in Postoperative pain (n=60). Gabapentin vs. Placebo was evaluated on Mean number of rescue analgesic doses required over 12 hours postoperatively (p=<0.001). Pre-emptive oral gabapentin (600 mg) significantly reduced the mean number of rescue analgesic doses required (2.1 vs 4.3, p<0.001) compared to placebo in women undergoing abdominal hysterectomy.
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