Key result
Preemptive gabapentin before abdominal hysterectomy significantly decreased 24-hour postoperative VAS pain scores (SMD -1.03; 95% CI -1.36 to -0.71) and reduced postoperative nausea (RR 0.76).
Why the study?
Does preemptive gabapentin reduce postoperative pain and narcotic consumption in women undergoing abdominal hysterectomy?
Population
891 women who underwent a total abdominal hysterectomy under general anesthesia
Comparison
Preemptive gabapentin, with or without… vs Control (placebo)
Design
Meta-analysis, randomized, double-blind
Follow-up
24 hours
Authors
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Preemptive gabapentin reduces 24-hour opioid use, pain scores, and nausea after hysterectomy; reinforces pooled RCT evidence for perioperative adoption.
Meta-Analysis (n=891)
Double-blind
Randomized
Does preemptive gabapentin reduce postoperative pain and narcotic consumption in women undergoing abdominal hysterectomy?
Standardized Mean Difference: -1.03 (95% CI -1.36–-0.71)
Preemptive gabapentin effectively decreases postoperative pain scores, narcotic consumption, and nausea at 24 hours in women undergoing abdominal hysterectomy.
Alayed et al. (2014) conducted a meta-analysis in abdominal hysterectomy (n=891). Preemptive gabapentin vs. Control was evaluated on visual analog scale (VAS) pain scores 24 hours postoperatively (SMD -1.03, 95% CI -1.36 to -0.71). Preemptive gabapentin before abdominal hysterectomy significantly decreased 24-hour postoperative VAS pain scores (SMD -1.03; 95% CI -1.36 to -0.71) and reduced postoperative nausea (RR 0.76).
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