Key result
A single preoperative oral dose of pregabalin reduced postoperative pain scores and analgesic consumption compared to gabapentin and placebo in patients undergoing elective abdominal hysterectomy.
Why the study?
The study was designed to evaluate and compare the efficacy of a single preoperative dose of pregabalin and gabapentin for attenuating postoperative pain and analgesic consumption after abdominal hysterectomy.
Does a single preoperative dose of pregabalin or gabapentin reduce postoperative pain and analgesic consumption in patients undergoing abdominal hysterectomy?
RCT (n=90)
Double-blind
Randomly allocated
No
Does a single preoperative dose of pregabalin or gabapentin reduce postoperative pain and analgesic consumption in patients undergoing abdominal hysterectomy?
A single preoperative dose of pregabalin 300 mg provides superior postoperative analgesia and reduces analgesic consumption compared to gabapentin 900 mg and placebo in patients undergoing abdominal hysterectomy, though it is associated with increased drowsiness and dizziness.
Answers are grounded in this paper and cite their sources.
Supports preoperative pregabalin 300 mg for hysterectomy analgesia; extends comparative RCT data on gabapentinoids.
Objectives: This study was designed to evaluate and compare the efficacy of a single preoperative dose of pregabalin and gabapentin for attenuating postoperative pain and analgesic consumption after abdominal hysterectomy. Methods: 90 patients of ASA grade I or II were randomly allocated to three groups, with 30 patients in each group. Patients in Group A were given Pregabalin 300mg, Group B were given Gabapentin 900mg and Group C patients received placebo 1 hour prior to surgery. Postoperative pain was assessed by a 100mm visual analogue scale.
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Arshid Ahmad Sofi (2019) conducted an RCT in Postoperative pain after abdominal hysterectomy (n=90). Pregabalin vs. Placebo was evaluated on Postoperative pain score (VAS) at 1 hour (p=<0.001). A single preoperative oral dose of pregabalin reduced postoperative pain scores and analgesic consumption compared to gabapentin and placebo in patients undergoing elective abdominal hysterectomy.
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