Key result
Low-dose gabapentin significantly reduced postoperative pain intensity at 2 hours (38.9 vs 74.9 on a 100 mm scale, p<0.05) and decreased opioid requirements compared to placebo after abdominal hysterectomy.
Why the study?
Does low-dose gabapentin reduce postoperative pain in patients undergoing abdominal hysterectomy?
Population
98 patients undergoing abdominal hysterectomy
Comparison
Oral gabapentin 400 mg 1 hour before surgery… vs Placebo
Design
RCT, randomised, double-blind
Follow-up
24 hours
Authors
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Low-dose gabapentin reduces early pain and opioid needs after abdominal hysterectomy; supports perioperative use and extends gabapentinoid evidence in gynecologic surgery.
RCT (n=98)
Double-blind
Computer-generated random number table
No
Does low-dose gabapentin reduce postoperative pain in patients undergoing abdominal hysterectomy?
Absolute Event Rate: 38.9% vs 74.9%
p-value: p=<0.05
Low-dose gabapentin administered perioperatively significantly reduces early postoperative pain following abdominal hysterectomy.
Sekhavat et al. (2009) conducted an RCT in Elective abdominal hysterectomy for benign conditions (n=98). Gabapentin vs. Placebo was evaluated on Postoperative pain intensity at 2 hours (100 mm visual analogue scale) (p=<0.05). Low-dose gabapentin significantly reduced postoperative pain intensity at 2 hours (38.9 vs 74.9 on a 100 mm scale, p<0.05) and decreased opioid requirements compared to placebo after abdominal hysterectomy.
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