Key result
Preoperative single-dose gabapentin significantly reduced acute postoperative pain, tramadol consumption, and long-term pain scores up to 6 months compared with placebo (P<0.05).
Why the study?
Does preoperative single-dose gabapentin reduce acute and chronic postoperative pain in male patients undergoing inguinal herniorrhaphy?
Population
60 male patients, aged 20-40 years, scheduled for unilateral inguinal herniorrhaphy under spinal anaesthesia
Comparison
Single-dose 1.2 g oral gabapentin 1 h before… vs Placebo capsule 1 h before surgery
Design
RCT, Randomly allocated to two groups, Double-blind
Follow-up
6 months
Authors
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Supports preoperative gabapentin for inguinal herniorrhaphy to cut acute and chronic pain; extends RCT evidence for perioperative gabapentinoids.
RCT (n=60)
Double-blind
Randomized
Does preoperative single-dose gabapentin reduce acute and chronic postoperative pain in male patients undergoing inguinal herniorrhaphy?
p-value: p=<0.05
Preoperative single-dose gabapentin effectively reduces both acute postoperative pain and chronic pain up to 6 months after inguinal herniorrhaphy.
Şen et al. (2009) conducted an RCT in Inguinal herniorrhaphy (n=60). Gabapentin vs. Placebo was evaluated on Visual analogue scale scores (lying and sitting) and total tramadol consumption at 8, 12, 16, 20 and 24 h after surgery (p=<0.05). Preoperative single-dose gabapentin significantly reduced acute postoperative pain, tramadol consumption, and long-term pain scores up to 6 months compared with placebo (P<0.05).
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