Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 30, 2015PainOpen Access

Analgesic and sedative effects of perioperative gabapentin in total knee arthroplasty

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does perioperative gabapentin reduce pain upon ambulation in opioid-naive patients undergoing total knee arthroplasty?

Population

300 opioid-naive patients scheduled for total knee arthroplasty

Comparison

Gabapentin 1300 mg/d or 900 mg/d daily from 2… vs Placebo daily from 2 hours preoperatively to…

Design

RCT, 1:1:1, double-blind, placebo-controlled

Follow-up

postoperative day 6

Authors

TLTroels Haxholdt LunnHHHenrik HustedMLMogens Berg Laursen

Discussion

Loading...

Member takes

Overview

Does not support routine perioperative gabapentin for ambulation pain after total knee arthroplasty; challenges assumptions from earlier trials in opioid-naive patients.

Key Points

  • To determine the dose-dependent analgesic and sedative effects and safety of perioperative gabapentin in opioid-naive patients undergoing total knee arthroplasty.
  • Randomized, double-blind, placebo-controlled dose-finding trial of 300 opioid-naive patients scheduled for total knee arthroplasty.
  • Participants were randomized (1:1:1) to receive gabapentin 1300 mg/day (group A), gabapentin 900 mg/day (group B), or placebo (group C) daily from 2 hours preoperatively to postoperative day 6 alongside standardized multimodal analgesia.
  • Pain upon ambulation on a visual analog scale at 24 hours was 41 (95% CI, 37–46) in group A vs 41 (95% CI, 36–45) in group B vs 42 (95% CI, 37–47) in group C (P = 0.93).
  • Sedation at 6 hours on a numeric rating scale was 3.2 (range, 0–10) in group A vs 2.6 (range, 0–9) in group B vs 2.3 (range, 0–9) in group C, with a mean difference between group A and C of 0.9 (95% CI, 0.2–1.7; P = 0.046).
  • No significant differences occurred in overall pain or morphine consumption through day 6, but group A had more dizziness from days 2–6 and more severe adverse reactions than groups B and C.

Structured PICO

Does perioperative gabapentin reduce pain upon ambulation in opioid-naive patients undergoing total knee arthroplasty?

P
Population
300 opioid-naive patients scheduled for total knee arthroplasty
I
Intervention
Gabapentin 1300 mg/d or 900 mg/d daily from 2 hours preoperatively to postoperative day 6 in addition to a standardized multimodal analgesic regime
C
Comparator
Placebo daily from 2 hours preoperatively to postoperative day 6 in addition to a standardized multimodal analgesic regime
O
Outcome
Pain upon ambulation 24 hours after surgerypatient reported

Perioperative gabapentin does not improve acute postoperative pain in opioid-naive patients undergoing total knee arthroplasty and is associated with increased sedation and adverse reactions.

Cite This Study

Lunn et al. (2015) studied this question.

synapsesocial.com/papers/6a87d003f762332bf8fe7ff2https://doi.org/10.1097/j.pain.0000000000000309
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adverse effects of perioperative paracetamol, NSAID s, glucocorticoids, gabapentinoids and their combinations: a topical review2014 · 152 citations
  2. 2The Pain Catastrophizing Scale: Development and validation.1995 · 7,861 citations
  3. 3Gabapentin and postoperative pain – a systematic review of randomized controlled trials2006 · 419 citations
  4. 4Single dose oral gabapentin for established acute postoperative pain in adults2010 · 112 citations
  5. 5Post‐operative analgesic effects of paracetamol, <scp>NSAIDs</scp>, glucocorticoids, gabapentinoids and their combinations: a topical review2014 · 154 citations