Why the study?
Preemptive gabapentin may help prevent central neuronal sensitization with minimal adverse effects, but its effectiveness for pain relief, opioid-sparing potential, sedation, and side effects required evaluation.
Does preoperative gabapentin 800 mg compared to 400 mg improve postoperative pain control and reduce opioid consumption in patients undergoing orthopedic surgery under spinal anesthesia?
Population
80 ASA grade I and II patients undergoing orthopedic surgery
Comparison
Preoperative gabapentin 800 mg vs 400 mg
Design
Randomized trial
Follow-up
24 h
Authors
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Preoperative gabapentin may reduce pain and opioid use after orthopedic surgery under spinal anesthesia; leaves open need for confirmatory RCTs.
Does preoperative gabapentin 800 mg compared to 400 mg improve postoperative pain control and reduce opioid consumption in patients undergoing orthopedic surgery under spinal anesthesia?
Preoperative administration of 800 mg gabapentin is more effective than 400 mg in enhancing postoperative pain control and reducing opioid use in orthopedic patients.
Singh et al. (2025) studied this question.
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