Why the study?
Gabapentin and pregabalin may attenuate central sensitization and decrease postoperative pain, but their preemptive analgesic efficacy needed evaluation in patients undergoing lower limb orthopedic surgery under spinal anesthesia.
Does preemptive oral gabapentin 600 mg improve postoperative analgesia compared to oral pregabalin 75 mg in patients undergoing lower limb orthopedic surgery under spinal anesthesia?
Population
70 patients aged 18 to 60 years with ASA grade 1 and 2 undergoing lower limb orthopedic surgery
Comparison
Oral gabapentin 600 mg vs oral pregabalin 75 mg
Design
Prospective, randomized, double-blind study
Follow-up
24 hours
Authors
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Favors gabapentin over pregabalin for preemptive analgesia in lower limb orthopedic surgery; extends head-to-head data on gabapentinoids.
Does preemptive oral gabapentin 600 mg improve postoperative analgesia compared to oral pregabalin 75 mg in patients undergoing lower limb orthopedic surgery under spinal anesthesia?
A single preemptive dose of oral gabapentin 600 mg provides superior and longer-lasting postoperative analgesia than oral pregabalin 75 mg for lower limb orthopedic surgeries.
Jain et al. (2021) studied this question.
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