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August 16, 2026CureusOpen Access

Outcomes of Patients With Appendiceal Neoplasms Based on Clinicopathological Features and Surgical Intervention: A Retrospective Observational Study at a Tertiary Cancer Centre in India

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Authors

NGNikhil GargSMSenthilkumar MoorthyVWVikas Warikoo

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Overview

Retrospective cohort study reveals superior survival in low-grade appendiceal neoplasms, indicating that tumor biology drives patient prognosis.

Key Points

  • To evaluate the clinicopathological characteristics, treatment approaches, and overall survival outcomes across different histological subtypes of appendiceal neoplasms.
  • Retrospective observational study of 55 patients with histologically confirmed appendiceal neoplasms treated between January 2021 and December 2025 at a tertiary cancer center in India.
  • Evaluated patient demographics, tumor stage, histological classification, recurrence status, and surgical approaches (appendectomy alone versus other surgical procedures).
  • Low-grade appendiceal mucinous neoplasm (LAMN) was the most common subtype (67.3%, n=37) and was associated with significantly superior overall survival compared to other subtypes (log-rank p = 0.026; HR = 0.24, p = 0.040).
  • Among patients with LAMN histology, overall survival did not differ significantly between appendectomy alone and other surgical procedures (log-rank p = 0.48), with both cohorts maintaining >85% 3-year survival rates.

Cite This Study

Garg et al. (2026) studied this question.

synapsesocial.com/papers/6a81799af2fb91fc834acd22https://doi.org/10.7759/cureus.114520
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Appendiceal Mucinous Neoplasms: Diagnosis and Management2017 · 243 citations
  2. 2Analysis of Clinical Characteristics of Low-Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Cohort Study of 51 LAMN Patients2020 · 33 citations
  3. 3Right hemicolectomy does not confer a survival advantage in patients with mucinous carcinoma of the appendix and peritoneal seeding2004 · 304 citations
  4. 4Peritonectomy Procedures1995 · 1,554 citations
  5. 5Classification of and cytoreductive surgery for low-grade appendiceal mucinous neoplasms2012 · 108 citations