Beta-adrenoceptor-mediated renin release in response to stress is blunted in older rats compared to young rats.
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Age blunts beta-adrenoceptor-mediated renin release to stress in rats; hypothesis-generating with unclear translation to human aging or therapy.
Plasma renin activity (PRA) was similar in young versus old male Sprague Dawley rats under unstressed conditions (1.3 +/- 0.2 versus 1.8 +/- 0.3 ng angiotensin I/ml per min). Airjet stress increases PRA in young but not old rats (13.9 +/- 3.8 versus 2.9 +/- 0.8 ng angiotensin I/ml per min), respectively. This response is ablated in young rats by beta-adrenoceptor blockade, suggesting that the increased PRA is mediated by beta-adrenoceptors, and this response was blunted in old rats.
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Baylis et al. (1998) studied this question.
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