Key result
A bovine kidney cell line stably expressing αVβ6 integrin (LFBK-αVβ6) was highly sensitive for detecting all serotypes of FMDV and more effective than other cell types for virus isolation.
Population
Bovine kidney cell line
Comparison
Transduction to stably express both αV and β6… vs Other cell types currently used for virus…
Design
Preclinical
Follow-up
≥ 100 cell passages
Authors
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May enhance FMDV isolation in veterinary labs; leaves open translation to routine diagnostics without field validation.
The engineered LFBK-αVβ6 cell line provides a more sensitive and stable tool for the isolation and detection of Foot-and-Mouth Disease Virus from clinical samples.
LaRocco et al. (2013) studied Foot-and-mouth disease. LFBK-αVβ6 cell line vs. Other cell types currently used for virus isolation was evaluated on Detection of FMDV in clinical samples. A bovine kidney cell line stably expressing αVβ6 integrin (LFBK-αVβ6) was highly sensitive for detecting all serotypes of FMDV and more effective than other cell types for virus isolation.
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