What is the clinical evidence from this study?

Population: Foot-and-Mouth Disease Virus (FMDV) tropism. Intervention: Integrin-alpha(v)beta(6) expression analysis. Primary outcome: Tissue distribution of integrin-alpha(v)beta(6).

What does this research mean for the field?

Integrin-alpha(v)beta(6) is constitutively expressed in the normal airways of cattle and sheep, presenting an accessible target for foot-and-mouth disease virus infection via inhalation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 3, 2006Journal of Histochemistry & Cytochemistry

Integrin-α v β 6 , a Putative Receptor for Foot-and-Mouth Disease Virus, Is Constitutively Expressed in Ruminant Airways

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Key result

Integrin alphavbeta6 expression in normal ruminant airways suggests high susceptibility to inhaled FMDV infection.

Authors

JBJeremy K. BrownMRC Centre for Reproductive Health SMSybil M. McAleeseScotland's Rural College ETElisabeth M. ThorntonRoslin Institute

Discussion

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Implication

Supports integrin targeting for FMDV studies in ruminants; leaves open whether this informs vaccines or antivirals.

PICO

Population

Foot-and-Mouth Disease Virus (FMDV) tropism

Exposure / Comparator

Integrin-alpha(v)beta(6) expression analysis

Primary Outcome

Tissue distribution of integrin-alpha(v)beta(6)

Cite This Study

Brown et al. (2006) studied Foot-and-Mouth Disease Virus (FMDV) tropism. Integrin-alpha(v)beta(6) expression analysis was evaluated on Tissue distribution of integrin-alpha(v)beta(6). Integrin-alpha(v)beta(6) is constitutively expressed in the normal airways of cattle and sheep, suggesting ruminant airway epithelium is a highly accessible target for FMDV infection by inhalation.

synapsesocial.com/papers/6aa556cb3f91f0dc5278eaf4 https://doi.org/10.1369/jhc.5a6854.2006

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Integrin-α v β 6 , a Putative Receptor for Foot-and-Mouth Disease Virus, Is Constitutively Expressed in Ruminant Airways

Discussion

Member takes

Implication

PICO

Cite This Study

Integrin-α v β 6 , a Putative Receptor for Foot-and-Mouth Disease Virus, Is Constitutively Expressed in Ruminant Airways

Discussion

Member takes

Implication

PICO

Cite This Study

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Also Consider