Key result
The AT1R A1166C polymorphism was significantly associated with an increased risk of pregnancy-induced hypertension, with the C allele conferring a higher risk compared to the A allele (OR 2.14).
Why the study?
Does the AT1R A1166C polymorphism increase the risk of pregnancy-induced hypertension in pregnant women?
Meta-Analysis (n=2,328)
Does the AT1R A1166C polymorphism increase the risk of pregnancy-induced hypertension in pregnant women?
Odds Ratio: 2.14 (95% CI 1.54–2.98)
p-value: p=<0.00001
The AT1R A1166C polymorphism is significantly associated with an increased risk of pregnancy-induced hypertension, particularly in Asian populations.
May inform genetic risk assessment for pregnancy-induced hypertension; leaves open prospective validation before clinical use.
PURPOSE: The purpose of this study was to perform a quantitative review of previous case control studies examining the association between AT1R A1166C polymorphism and pregnancy-induced hypertension (PIH). MATERIALS AND METHODS: Odds ratio (OR) and 95% confidence intervals (CI) were used as measures of effect sizes. Overall effect sizes were derived using a random-effects model or fixed-effects model when appreciated, and stratified by ethnicity. Funnel plots and Egger's regression asymmetry tests were utilized for publication bias detection. RESULTS: A total of ten articles (including 920 PIH cases and 1408 controls) were included in this meta-analysis. The overall effect sizes (OR = 2.14, 95% CI: 1.54-2.98, p < 0.00001) of additive model indicated PIH patients had a significant higher frequency of allele C. Meanwhile, the OR of the dominant model was 2.22 (95% CI: 1.51-3.26,p < 0.00001) which signified that PIH patients also had a significant higher frequency of AC+CC genotypes. The subgroup analyses were in line with the overall outcomes except the Caucasians PIH patients had a non-significant CA+CC genotypes (OR = 1.37, 95% CI: 0.95-1.98, p > 0.05). The Egger's test of additive model (p = 0.451) and dominant model (p = 0.623) revealed no statistical significance for publication bias. CONCLUSION: The meta-analysis suggested that the AT1R Al166C polymorphism was significantly associated with the PIH, especially in Asian subjects.
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Wang et al. (2015) conducted a meta-analysis in Pregnancy-induced hypertension (n=2,328). AT1R A1166C polymorphism vs. Allele A or AA genotype was evaluated on Risk of pregnancy-induced hypertension (additive model, C vs A allele) (OR 2.14, 95% CI 1.54-2.98, p=<0.00001). The AT1R A1166C polymorphism was significantly associated with an increased risk of pregnancy-induced hypertension, with the C allele conferring a higher risk compared to the A allele (OR 2.14).
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