Why the study?
Are polymorphisms of angiotensin II type 1 and type 2 receptors associated with pregnancy-induced hypertension and preeclampsia?
Are polymorphisms of angiotensin II type 1 and type 2 receptors associated with pregnancy-induced hypertension and preeclampsia?
The A1675G polymorphism of the angiotensin II type 2 receptor may be a genetic risk factor for preeclampsia.
May support preeclampsia risk stratification; leaves open clinical utility pending prospective validation.
BACKGROUND: To assess whether the polymorphisms of angiotensin II type 1 and type 2 receptors (AT1R, AT2R) are associated with pregnancy-induced hypertension (PIH) and preeclampsia. METHODS: Studies were searched from PubMed, ISI Web of Science and HuGE Navigator. RESULTS: The A1166C polymorphism of AT1R, A1675G and C3123A polymorphisms of AT2R were analyzed. Significant association was found in recessive model (OR = 1.581, 95% confidence interval (CI): 1.054-2.371) and co-dominant (GG versus AG) model (OR = 1.900, 95%CI: 1.001-3.604) between the A1675G polymorphism and preeclampsia. No association was found between the other polymorphisms and PIH or preeclampsia. CONCLUSIONS: The A1675G polymorphism might be associated with preeclampsia, but the A1166C and C3123A polymorphisms had no effect on PIH or preeclampsia.
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Li et al. (2015) studied this question.
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