Key result
Polymorphisms and haplotypes of the AT2R gene (rs5193, rs1403543, rs12710567) were not associated with the risk of pregnancy induced hypertension in Chinese Han women.
Why the study?
Are angiotensin receptor 2 (AT2R) gene polymorphisms associated with the risk of pregnancy induced hypertension in Chinese Han women?
Case-Control (n=1,096)
Are angiotensin receptor 2 (AT2R) gene polymorphisms associated with the risk of pregnancy induced hypertension in Chinese Han women?
Answers are grounded in this paper and cite their sources.
Polymorphisms in the angiotensin receptor 2 gene (rs5193, rs1403543, rs12710567) do not appear to influence the risk of pregnancy-induced hypertension in Chinese Han women.
OBJECTIVES: To investigate the association of polymorphisms and haplotypes of angiotensin receptor 2 (AT2R) gene with pregnancy induced hypertension (PIH) in Chinese Han women. METHODS: A case-control study was designed with 446 cases (gestational hypertension, GH: 124; pre-eclampsia, PE + eclampsia, E: 322) and 650 controls. rs5193, rs1403543 and rs12710567 of AT2R gene were genotyped. A logistic regression approach was applied to estimate the relationship between the polymorphisms and haplotypes of AT2Rgene with PIH risk. RESULTS: No relationship between AT2R gene polymorphisms and PIH was detected. The haplotype analysis also showed a negative result. CONCLUSIONS: rs5193, rs1403543 and rs12710567 of AT2R gene might have no effect on PIH risk among Chinese Han women.
No takes yet. Share an insight, caveat, or question.
Li et al. (2018) conducted a case-control in Pregnancy induced hypertension (PIH) (n=1,096). AT2R gene polymorphisms (rs5193, rs1403543, rs12710567) vs. Controls was evaluated on Pregnancy induced hypertension (PIH) risk. Polymorphisms and haplotypes of the AT2R gene (rs5193, rs1403543, rs12710567) were not associated with the risk of pregnancy induced hypertension in Chinese Han women.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: