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November 14, 2002HeartOpen Access

β Blockers in older persons with heart failure: tolerability and impact on quality of life

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Why the study?

Does bisoprolol improve tolerability, symptoms, and exercise tolerance in older patients with stable symptomatic heart failure?

Population

51 older patients with stable symptomatic heart failure caused by left ventricular systolic dysfunction.

Design

Cohort

Authors

ABAmanda BaxterTexas A&M University

Discussion

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Implication

Supports cautious bisoprolol use in older HF; hypothesis-generating for health status gains, needing RCTs before practice change.

Key Points

  • To evaluate the tolerability and associated symptom changes of initiating bisoprolol therapy in older patients with heart failure.
  • Prospective observational cohort study conducted in a university hospital geriatric medicine outpatient department.
  • Included 51 patients (mean age 78 years, range 70–89 years) with stable symptomatic heart failure due to left ventricular systolic dysfunction.
  • Administered bisoprolol tablets titrated over time within a dose range of 1.25 mg to 10.0 mg.
  • Bisoprolol was tolerated by 69% of patients, reaching a mean tolerated dose of 7.6 mg.
  • Patients tolerating the drug showed no significant change in symptoms or exercise capacity, while perceived health status and anxiety and depression scores improved during titration.
  • Treatment withdrawal occurred at twice the rate previously observed in younger patient populations.

Structured PICO

Does bisoprolol improve tolerability, symptoms, and exercise tolerance in older patients with stable symptomatic heart failure?

P
Population
51 older patients (mean age 78 years, range 70-89 years) with stable symptomatic heart failure caused by left ventricular systolic dysfunction.
I
Intervention
Bisoprolol tablets, 1.25-10.0 mg
O
Outcome
Tolerability; changes in symptoms and exercise tolerancepatient reported

In older patients with heart failure, bisoprolol is tolerated by 69% at doses similar to clinical trials, without worsening symptoms or exercise capacity, though withdrawal rates are higher than in younger populations.

Cite This Study

Amanda Baxter (2002) studied this question.

synapsesocial.com/papers/6a819f040e5cf6378306cebehttps://doi.org/10.1136/heart.88.6.611

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Digoxin in Heart Failure with a Reduced Ejection Fraction: A Risk Factor or a Risk Marker?2016 · 871 citations
  2. 2Incidence and aetiology of heart failure; a population-based study1999 · 715 citations
  3. 3The epidemiology of heart failure1997 · 1,019 citations