What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Apparently healthy individuals without a history of cardiovascular disease (n=868). Intervention: Estimated 10-year absolute risk of CAD death (JAS guidelines 2012 categories) vs. Lower risk categories. Primary outcome: Mean carotid intima-media thickness (IMT) in mm (p=<0.001).

What question did this study set out to answer?

To determine whether subclinical carotid artery atherosclerosis corresponds to the 10-year risk of coronary artery disease death defined by the 2012 Japan Atherosclerosis Society guidelines.

January 1, 2013Journal of Atherosclerosis and ThrombosisOpen Access

Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Q: What are the key findings of this study?

The estimated 10-year absolute risk of CAD death and JAS guidelines 2012 categories were directly related to increased carotid intima-media thickness and plaque number in apparently healthy Japanese men.

Q: What question did this study set out to answer?

To determine whether subclinical carotid artery atherosclerosis corresponds to the 10-year risk of coronary artery disease death defined by the 2012 Japan Atherosclerosis Society guidelines.

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Key result

The estimated 10-year absolute risk of CAD death and JAS guidelines 2012 categories were directly related to increased carotid intima-media thickness and plaque number in apparently healthy Japanese men.

Key Points

To determine whether subclinical carotid artery atherosclerosis corresponds to the 10-year risk of coronary artery disease death defined by the 2012 Japan Atherosclerosis Society guidelines.
Assessed 868 randomly selected Japanese men aged 40 to 74 years without a history of cardiovascular disease in Kusatsu City, Japan between 2006 and 2008.
Measured carotid intima-media thickness (IMT) and plaque count using ultrasonography, categorizing individuals into risk Categories I, II, and III based on NIPPON DATA80 charts.
Carotid IMT increased across guideline risk tiers, measuring 0.70 ± 0.11 mm in Category I, 0.81 ± 0.16 mm in Category II, and 0.88 ± 0.18 mm in Category III.
Mean plaque count rose alongside risk category, averaging 0.9 plaques in Category I, 2.1 in Category II, and 3.0 in Category III.
Mean IMT was directly associated with 10-year estimated coronary artery disease death risk, reaching 0.88 ± 0.18 mm for risk ≥ 2.0% and 0.95 ± 0.19 mm for risk ≥ 5.0%.

Study Design

Type

Cross-Sectional (n=868)

Multicenter

Structured PICO

Population

868 apparently healthy Japanese men aged 40 to 74 years without a history of cardiovascular disease who underwent carotid ultrasound examinations.

Outcome

Intima media thickness (IMT) and plaque number from the common to internal carotid arteries measured using ultrasonographysurrogate

Main Result

Absolute Event Rate: 0.88% vs 0.7%

p-value: p=<0.001

Limitations

Family history was not considered during risk classification
Conducted in men only, so results may not be applicable to women
Used IMT as a surrogate marker of subclinical atherosclerosis, although the predictive value of the progression of IMT is in debate

Discussion

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Implication

Carotid IMT and plaque burden correlate well with the estimated 10-year absolute risk of CAD death and risk categories defined by the 2012 Japan Atherosclerosis Society guidelines.

Cite This Study

Kadota et al. (2013) conducted a cross-sectional in Apparently healthy individuals without a history of cardiovascular disease (n=868). Estimated 10-year absolute risk of CAD death (JAS guidelines 2012 categories) vs. Lower risk categories was evaluated on Mean carotid intima-media thickness (IMT) in mm (p=<0.001). The estimated 10-year absolute risk of CAD death and JAS guidelines 2012 categories were directly related to increased carotid intima-media thickness and plaque number in apparently healthy Japanese men.

synapsesocial.com/papers/6a819f1628bb6950eb60f357 https://doi.org/10.5551/jat.17244

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Implication

Carotid IMT and plaque burden correlate well with the estimated 10-year absolute risk of CAD death and risk categories defined by the 2012 Japan Atherosclerosis Society guidelines.

Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Key Points

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Key Points

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Also Consider

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