Key result
Patients with HFpEF had significantly higher rates of chronotropic incompetence during maximal exercise compared to healthy controls (63% vs 2%, P<0.001).
Why the study?
Do patients with HFpEF have impaired chronotropic response and heart rate recovery during and after exercise compared to healthy and hypertensive controls?
Population
98 participants including 41 patients with heart failure with preserved ejection fraction, 41 healthy…
Design
Cross-sectional
Authors
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Chronotropic incompetence may contribute to HFpEF exercise intolerance; hypothesis-generating and requires prospective trials before practice change.
Case-Control (n=98)
Do patients with HFpEF have impaired chronotropic response and heart rate recovery during and after exercise compared to healthy and hypertensive controls?
Absolute Event Rate: 63% vs 2%
p-value: p=<0.001
Patients with HFpEF exhibit significant chronotropic incompetence and impaired heart rate recovery during and after exercise compared to healthy controls, which may contribute to their exercise intolerance.
Phan et al. (2009) conducted a case-control in Heart failure with preserved ejection fraction (HFpEF) (n=98). Heart failure with preserved ejection fraction (HFpEF) vs. Healthy controls and hypertensive controls was evaluated on Chronotropic incompetence (measured by percentage of HR reserve used during maximal exercise) (p=<0.001). Patients with HFpEF had significantly higher rates of chronotropic incompetence during maximal exercise compared to healthy controls (63% vs 2%, P<0.001).
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