Key result
Hypoalbuminemia predicted inferior event-free survival and overall survival in patients with pelvic PNET, and was associated with low BMI.
Why the study?
Does hypoalbuminemia predict inferior outcomes in patients with pelvic PNET?
Cohort (n=48)
Does hypoalbuminemia predict inferior outcomes in patients with pelvic PNET?
Pelvic PNET is associated with a high burden of metastases and poor outcomes, with hypoalbuminemia serving as a significant predictor of inferior event-free and overall survival.
Answers are grounded in this paper and cite their sources.
Hypoalbuminemia may stratify risk in pelvic PNET; hypothesis-generating and should not yet change practice.
Data on prognostic factors in pelvic PNET are minimal. We analyzed patients with pelvic PNET treated between June 2003 and November 2011 for prognostic factors. Forty-eight (13%) of 374 patients with PNET were pelvic PNET with median age 14.5 years (range: 5-33); 31 (65%) had metastases. After median follow-up of 20.4 months (range: 1.3-64.9), 3-year EFS, OS, and local-control-rate were 13.5 ± 5.5%, 15.4 ± 9%, and 41.3 ± 14.9%, respectively. Hypoalbuminemia (≤3.4 g/dl) predicted inferior EFS and OS for both entire cohort and metastatic group. All patients with hypoalbuminemia (n = 10) had low BMI as compared to 23/38 without hypoalbuminemia (P = 0.02).
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Biswas et al. (2013) conducted a cohort in Pelvic primitive neuroectodermal tumor (PNET) (n=48). Hypoalbuminemia (≤3.4 g/dl) vs. Without hypoalbuminemia was evaluated on Event-free survival (EFS) and overall survival (OS). Hypoalbuminemia predicted inferior event-free survival and overall survival in patients with pelvic PNET, and was associated with low BMI.
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