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July 1, 1995British Journal of Clinical PharmacologyOpen Access

The role of the renin‐angiotensin and natriuretic peptide systems in the pulmonary vasculature.

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Authors

RCRI CargillUniversity of DundeeBLBJ LipworthUniversity of Dundee

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Implication

Hypothesis-generating for pulmonary hypertension therapies; prospective trials needed before clinical consideration.

Key Points

  • To review the physiological functions and regulatory interactions of the renin-angiotensin and natriuretic peptide systems within the pulmonary circulation.
  • Synthesized findings from human and experimental animal models evaluating vasoactive peptide behavior in pulmonary vascular beds.
  • Assessed endocrine responses, peptide elevations in conditions such as cor pulmonale, and mechanisms regulating hypoxic pulmonary vasoconstriction.
  • Angiotensin II levels are elevated in pulmonary hypertension and act synergistically with hypoxaemia to intensify hypoxic pulmonary vasoconstriction, an effect attenuated by pharmacological blockade.
  • Atrial and brain natriuretic peptides (ANP and BNP) exhibit direct pulmonary vasorelaxant activity in humans, mitigating hypoxic vasoconstriction and counteracting angiotensin II-induced vasoconstriction.

Cite This Study

Cargill et al. (1995) studied this question.

synapsesocial.com/papers/6a81d3f971edfdad573c8d7ehttps://doi.org/10.1111/j.1365-2125.1995.tb04528.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elevated levels of brain natriuretic peptide in acute hypoxaemic chronic obstructive pulmonary disease1992 · 81 citations
  2. 2Human C-type natriuretic peptide: effects on the haemodynamic and endocrine responses to angiotensin II1995 · 22 citations
  3. 3Effect of angiotensin on hypoxic pulmonary vasoconstriction in isolated dog lung1976 · 30 citations
  4. 4Subcellular localization of pulmonary antiotensin-converting enzyme (kininase II)1975 · 298 citations
  5. 5Pulmonary vasorelaxant activity of atrial natriuretic peptide and brain natriuretic peptide in humans.1995 · 34 citations