Why the study?
Fosinopril has shown renoprotective effects in diabetic nephropathy, but the underlying mechanisms are not fully understood.
Population
Streptozotocin-induced diabetic C57BL/6J mice and stimulated HK2 cells
Comparison
Oral fosinopril administration vs controls
Design
Preclinical animal and in vitro mechanistic study
Follow-up
8 weeks
Authors
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May inform renoprotective strategies in diabetic nephropathy; leaves open human translation of SRC/NF-κB effects.
Fosinopril ameliorates renal injury in diabetic nephropathy models by inactivating the SRC/NF-κB pathway, providing mechanistic insight into its renoprotective effects.
Cheng et al. (2025) studied this question.
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