Population
Hepatitis C virus (HCV) internal ribosome entry site (IRES) domain II RNA constructs
Comparison
Selective deletion of bulge regions in domain II vs Wild-type or unmutated HCV IRES domain II
Design
Preclinical
Authors
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Supports structural role of HCV IRES domain II bulges in translation; hypothesis-generating for antivirals, requires validation before clinical consideration.
Mutations in the bulge regions of HCV IRES domain II disrupt translation efficiency by altering RNA secondary structure and p25 ribosomal protein cross-linking, supporting its structural role in translation.
Odreman-Macchioli et al. (2001) studied this question.
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