Population
HCV 5' UTR quasispecies isolated from the serum of a 46-year-old man with chronic hepatitis C, tested in…
Comparison
Transfection with bicistronic reporter vectors… vs Reference pIRF construct (wild-type HCV 1a 5' UTR)
Design
Preclinical
Follow-up
16 to 18 hours post-transfection
Authors
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Cell-type-specific HCV IRES activity is hypothesis-generating for quasispecies tropism; requires human validation before any clinical implications.
Naturally occurring sequence diversity in HCV 5' UTR quasispecies leads to cell-type-specific differences in translation efficiency, supporting the hypothesis of HCV multiple tropism.
Laporte et al. (2000) studied this question.
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