Population
BaF3 cells engineered to stably express Mpl (BaF3/Mpl) and primary megakaryocyte progenitors
Comparison
Thrombopoietin with or without… vs Untreated cells or cells without…
Design
Preclinical
Authors
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Cell model data should not change platelet disorder management; leaves open whether PI3K targeting modulates thrombopoiesis in vivo.
Phosphatidylinositol 3-kinase activity is necessary but not sufficient for thrombopoietin-induced cell cycle progression in megakaryocytic progenitors.
Geddis et al. (2001) studied this question.
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