March 8, 2012Journal of Hypertension
Association between asleep blood pressure and brain natriuretic peptide during antihypertensive treatment
Why the study?
Does the reduction in asleep blood pressure correlate with a reduction in brain natriuretic peptide during candesartan treatment in hypertensive patients?
Population
254 hypertensive patients with home SBP > 135 mmHg who underwent ambulatory BP monitoring
Comparison
Candesartan administered at bedtime vs Candesartan administered at awakening
Design
RCT, open-label
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
Reducing asleep SBP may lower cardiac stress during candesartan therapy; extends evidence for its independent role beyond awake BP.
Structured PICO
Does the reduction in asleep blood pressure correlate with a reduction in brain natriuretic peptide during candesartan treatment in hypertensive patients?
P
Population
254 hypertensive patients with home SBP > 135 mmHg who underwent ambulatory BP monitoring
I
Intervention
Candesartan (+ diuretics as needed) administered at bedtime
C
Comparator
Candesartan (+ diuretics as needed) administered at awakening
O
Outcome
Correlation between the decrease in log-transformed brain natriuretic peptide (BNP) and the decrease in asleep systolic blood pressure at 6 monthssurrogate
Reduction in asleep blood pressure during candesartan treatment is significantly associated with a decrease in BNP, independent of awake blood pressure changes.
Cite This Study
Shimizu et al. (2012) studied this question.