What question did this study set out to answer?

To evaluate the duration and magnitude of hepatitis A antigen excretion and subsequent antibody responses among cases and their household contacts during a localized epidemic.

January 1, 1977Journal of Medical Virology

Seroepidemiological investigation of patients and family contacts in an epidemic of hepatitis A

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Authors

GFGert FrösnerTechnical University of Munich LOLacy R. OverbyNofima BFBertram FlehmigCS Diagnostics

Discussion

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Implication

Outbreak investigation reveals viral shedding correlates with disease severity in hepatitis A contacts, indicating prolonged infectivity before jaundice.

Key Points

To evaluate the duration and magnitude of hepatitis A antigen excretion and subsequent antibody responses among cases and their household contacts during a localized epidemic.
Collected serial blood and faecal specimens from patients and family contacts during a village outbreak of hepatitis A.
Assayed specimens for hepatitis A antigen and antibodies using a solid-phase competitive radioimmunoassay.
Assessed long-term antibody persistence in 13 individuals 12 years after documented clinical jaundice.
Severe cases shed faecal antigen starting 11 days prior to jaundice and extending 10 days post-onset with peak excretion in late incubation, compared to only 2 days of low-level shedding in mild or subclinical cases.
A total of 79% (19/24) of infections occurred in individuals aged 0 to 20 years, an age group with a pre-existing antibody seroprevalence of only 6%.
Serum antibody titres increased from 1:20–1:40 at jaundice onset to 1:900–1:3500 over subsequent months, with mean titres persisting at 1:591 at 12 years post-infection (n=13).

Cite This Study

Frösner et al. (1977) studied this question.

synapsesocial.com/papers/6a825694f10a9fcdd646cc4a https://doi.org/10.1002/jmv.1890010303

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January 1, 1977Journal of Medical Virology

Seroepidemiological investigation of patients and family contacts in an epidemic of hepatitis A

View Full Paper

Ask AI

Bookmark

Authors

GFGert FrösnerTechnical University of Munich LOLacy R. OverbyNofima BFBertram FlehmigCS Diagnostics

Discussion

Member takes

Implication

Outbreak investigation reveals viral shedding correlates with disease severity in hepatitis A contacts, indicating prolonged infectivity before jaundice.

Key Points

To evaluate the duration and magnitude of hepatitis A antigen excretion and subsequent antibody responses among cases and their household contacts during a localized epidemic.
Collected serial blood and faecal specimens from patients and family contacts during a village outbreak of hepatitis A.
Assayed specimens for hepatitis A antigen and antibodies using a solid-phase competitive radioimmunoassay.
Assessed long-term antibody persistence in 13 individuals 12 years after documented clinical jaundice.
Severe cases shed faecal antigen starting 11 days prior to jaundice and extending 10 days post-onset with peak excretion in late incubation, compared to only 2 days of low-level shedding in mild or subclinical cases.
A total of 79% (19/24) of infections occurred in individuals aged 0 to 20 years, an age group with a pre-existing antibody seroprevalence of only 6%.
Serum antibody titres increased from 1:20–1:40 at jaundice onset to 1:900–1:3500 over subsequent months, with mean titres persisting at 1:591 at 12 years post-infection (n=13).

Cite This Study

Frösner et al. (1977) studied this question.

synapsesocial.com/papers/6a825694f10a9fcdd646cc4a https://doi.org/10.1002/jmv.1890010303

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