December 1, 1997Hepatology

Frequent detection of hepatitis A viral RNA in serum during the early convalescent phase of acute hepatitis A

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Why the study?

Can nested RT-PCR detect HAV RNA in the serum of patients with acute type A hepatitis during the early convalescent phase?

Population

58 patients, including 38 with type A acute hepatitis and 20 with non-A, non-B, non-C acute hepatitis.

Comparison

Detection of hepatitis A virus RNA in serum… vs Patients with non-A, non-B, non-C acute hepatitis.

Design

Cohort

Follow-up

Mean duration from onset of symptoms to disappearance of…

Authors

KFKeiichi FujiwaraOkayama Medical Center OYOsamu YokosukaChiba University TET EhataChiba University

Discussion

Member takes

Implication

Supports nested RT-PCR for HAV RNA detection in acute hepatitis A; hypothesis-generating and requires validation before changing diagnostics.

Structured PICO

Can nested RT-PCR detect HAV RNA in the serum of patients with acute type A hepatitis during the early convalescent phase?

Population

58 patients, including 38 with type A acute hepatitis and 20 with non-A, non-B, non-C acute hepatitis.

Intervention

Detection of hepatitis A virus (HAV) RNA in serum using nested reverse transcription-polymerase chain reaction (RT-PCR).

Comparator

Patients with non-A, non-B, non-C acute hepatitis.

Outcome

Presence of HAV RNA in serum and its correlation with alanine aminotransferase (ALT) and IgM-HA levels.surrogate

HAV RNA is frequently detectable in the serum of patients with acute type A hepatitis during the early convalescent phase and correlates with transaminase levels.

Cite This Study

Fujiwara et al. (1997) studied this question.

synapsesocial.com/papers/6a825644f10a9fcdd646cc26 https://doi.org/10.1002/hep.510260636

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December 1, 1997Hepatology

Frequent detection of hepatitis A viral RNA in serum during the early convalescent phase of acute hepatitis A

View Full Paper

Ask AI

Bookmark

Why the study?

Can nested RT-PCR detect HAV RNA in the serum of patients with acute type A hepatitis during the early convalescent phase?

Population

58 patients, including 38 with type A acute hepatitis and 20 with non-A, non-B, non-C acute hepatitis.

Comparison

Detection of hepatitis A virus RNA in serum… vs Patients with non-A, non-B, non-C acute hepatitis.

Design

Cohort

Follow-up

Mean duration from onset of symptoms to disappearance of…

Authors

KFKeiichi FujiwaraOkayama Medical Center OYOsamu YokosukaChiba University TET EhataChiba University

Discussion

Member takes

Implication

Supports nested RT-PCR for HAV RNA detection in acute hepatitis A; hypothesis-generating and requires validation before changing diagnostics.

Structured PICO

Can nested RT-PCR detect HAV RNA in the serum of patients with acute type A hepatitis during the early convalescent phase?

Population

58 patients, including 38 with type A acute hepatitis and 20 with non-A, non-B, non-C acute hepatitis.

Intervention

Detection of hepatitis A virus (HAV) RNA in serum using nested reverse transcription-polymerase chain reaction (RT-PCR).

Comparator

Patients with non-A, non-B, non-C acute hepatitis.

Outcome

Presence of HAV RNA in serum and its correlation with alanine aminotransferase (ALT) and IgM-HA levels.surrogate

HAV RNA is frequently detectable in the serum of patients with acute type A hepatitis during the early convalescent phase and correlates with transaminase levels.

Cite This Study

Fujiwara et al. (1997) studied this question.

synapsesocial.com/papers/6a825644f10a9fcdd646cc26 https://doi.org/10.1002/hep.510260636

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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