Why the study?
Can HAV RNA be detected in the serum of patients with acute hepatitis A infection?
Can HAV RNA be detected in the serum of patients with acute hepatitis A infection?
HAV RNA can be detected in the serum of patients with acute hepatitis A, particularly during early stages of the disease, and correlates with higher anti-HAV IgM titers.
Answers are grounded in this paper and cite their sources.
May support early HAV RNA testing in acute hepatitis A; leaves open its added value over IgM titers in prospective studies.
Hepatitis A virus (HAV) RNA was extracted from the sera of patients with acute hepatitis and then detected by molecular hybridization using cloned HAV complementary DNA (cDNA). HAV RNA was detected in 20 of 85 patients with acute HAV infection, mainly during the prodromal stage, or early during the icteric phase of the disease; it was detected as long as 21 days after its initial detection. Patients with HAV RNA in the serum had a significantly higher titer of anti-HAV IgM.
No takes yet. Share an insight, caveat, or question.
Oren et al. (1989) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: