Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 2002Journal of Viral Hepatitis

Quantification and duration of viraemia during hepatitis A infection as determined by real‐time RT‐PCR

View Full Paper
Ask AI
Bookmark
Share

Key result

In patients with hepatitis A infection, viraemia persisted for an average of 60 days after clinical onset, with mean viral loads of 6.38 x 10(5) copies/mL on the first day of diagnosis.

Population

41 HAV IgM positive serum samples and 200 serum samples from healthy blood donors

Design

Cohort

Follow-up

average of 60 days after clinical onset

Authors

MCMauro Costa‐MattioliUniversity of IowaSMSerge MonpoehoRegeneron (United States)ÉNÉlisabeth NicandAssistance Publique – Hôpitaux de Paris

Discussion

Loading...

Member takes

Implication

May warrant extended blood safety precautions in hepatitis A; leaves open validation of transmission risk in prospective cohorts.

Study Design

Type

Observational (n=241)

Structured PICO

P
Population
41 HAV IgM positive serum samples and 200 serum samples from healthy blood donors tested for HAV viraemia.
E
Exposure
Real-time RT-PCR with a dual-labelled fluorogenic probe to quantify the 5' noncoding region (5' NCR) of HAV
O
Outcome
Quantification and duration of viraemiasurrogate

Viraemia in hepatitis A infection lasts for many weeks, persisting for an average of 60 days after clinical onset.

Cite This Study

Costa‐Mattioli et al. (2002) conducted an observational in Hepatitis A infection (n=241). Hepatitis A infection vs. Healthy blood donors was evaluated on Duration and quantification of viraemia. In patients with hepatitis A infection, viraemia persisted for an average of 60 days after clinical onset, with mean viral loads of 6.38 x 10(5) copies/mL on the first day of diagnosis.

synapsesocial.com/papers/6a9a134bc99d08eca017c69ahttps://doi.org/10.1046/j.1365-2893.2002.00336.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Frequent detection of hepatitis A viral RNA in serum during the early convalescent phase of acute hepatitis A1997 · 56 citations
  2. 2Frequent detection of hepatitis A viral RNA in serum during the early convalescent phase of acute hepatitis A1997 · 48 citations
  3. 3Duration of Viremia in Hepatitis A Virus Infection2000 · 232 citations
  4. 4Hepatitis A Virus Infection in a Chimpanzee: Duration of Viremia and Detection of Virus in Saliva and Throat Swabs1989 · 98 citations
  5. 5Quantification of Enterovirus RNA in Sludge Samples Using Single Tube Real-Time RT-PCR2000 · 141 citations