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May 1, 1993Journal of Medical Virology

Duration of viremia in human hepatitis a viral infection as determined by polymerase chain reaction

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Why the study?

How long does viremia last in human hepatitis A viral infection when measured by RT-PCR?

Population

Patients with human hepatitis A viral (HAV) infection

Design

Cohort

Authors

HYHiroshi YotsuyanagiNational Institute of Infectious DiseasesSIShiro IinoUniversity of FukuiKKKazuhiko KoikeThe Japanese Society of Gastroenterological Surgery

Discussion

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Implication

Prolonged HAV viremia may raise blood-borne transmission risk; leaves open optimal screening duration and deferral policies.

Structured PICO

How long does viremia last in human hepatitis A viral infection when measured by RT-PCR?

P
Population
Patients with human hepatitis A viral (HAV) infection
I
Intervention
Detection of HAV genome in sera using RT-PCR method with primers in the 5' non-coding region
O
Outcome
Duration of HAV viremia relative to alanine aminotransferase (ALT) peak levels and seroconversionsurrogate

Viremia in hepatitis A infection lasts longer than the pre-symptomatic period, persisting after ALT peaks and seroconversion, which raises the possibility of secondary blood-borne infection.

Cite This Study

Yotsuyanagi et al. (1993) studied this question.

synapsesocial.com/papers/6a7051205671bbf00bc2b016https://doi.org/10.1002/jmv.1890400108
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular epidemiology of human hepatitis A virus defined by an antigen-capture polymerase chain reaction method.1990 · 270 citations
  2. 2Epidemiologic Patterns of Wild-Type Hepatitis A Virus Determined by Genetic Variation1991 · 143 citations
  3. 3Hepatitis A Virus Infection in a Chimpanzee: Duration of Viremia and Detection of Virus in Saliva and Throat Swabs1989 · 98 citations
  4. 4Detection of Hepatitis a Viral Antigen by Radioimmunoassay1975 · 121 citations
  5. 5Detection of serum hepatitis B virus DNA in patients with chronic hepatitis using the polymerase chain reaction assay.1989 · 301 citations