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July 1, 1996Hepatology

Prolonged Fecal Excretion of Hepatitis A Virus in Adult Patients With Hepatitis A As Determined by Polymerase Chain Reaction

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Key result

Fecal shedding of hepatitis A virus RNA was detected in 5 of 10 adult patients after symptom onset, lasting up to 3 months.

Population

10 adult patients with sporadic hepatitis A

Design

Cohort

Follow-up

up to 3 months

Authors

HYHiroshi YotsuyanagiNihon UniversityKKKazuhiko KoikeKanto Central HospitalKYKenji YASUDATokyo University of Agriculture

Discussion

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Implication

Supports caution on prolonged HAV transmission risk in adults; leaves open optimal isolation durations in larger cohorts.

Study Design

Type

Observational (n=10)

Structured PICO

P
Population
10 adult patients with sporadic hepatitis A evaluated for the duration of fecal HAV RNA shedding.
E
Exposure
Reverse-transcription (RT)-PCR system for detection of fecal HAV RNA
O
Outcome
Duration of fecal HAV RNA sheddingsurrogate

Fecal shedding of HAV can persist for up to 3 months after symptom resolution, suggesting a prolonged risk of viral transmission.

Cite This Study

Yotsuyanagi et al. (1996) conducted an observational in Hepatitis A (n=10). Hepatitis A virus infection was evaluated on Detection and duration of fecal HAV RNA shedding. Fecal shedding of hepatitis A virus RNA was detected in 5 of 10 adult patients after symptom onset, lasting up to 3 months.

synapsesocial.com/papers/6a99d7388fdb2eaad045a4c8https://doi.org/10.1002/hep.510240103
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prolonged fecal excretion of hepatitis A virus in adult patients with hepatitis A as determined by polymerase chain reaction1996 · 89 citations
  2. 2Faecal Excretion of Hepatitis a Virus in Patients with Symptomatic Hepatitis a Infection1981 · 24 citations
  3. 3Duration of viremia in human hepatitis a viral infection as determined by polymerase chain reaction1993 · 66 citations
  4. 4Excretion of Hepatitis A Virus (HAV) in Adults: Comparison of Immunologic and Molecular Detection Methods and Relationship between HAV Positivity and Infectivity in Tamarins1999 · 43 citations
  5. 5Quantification and duration of viraemia during hepatitis A infection as determined by real‐time RT‐PCR2002 · 100 citations